Giorgio Persano opened his first gallery, Multipli, in 1970. While developing an interest in American Pop graphics, he began producing multiplied artworks by Italian artists, such as Michelangelo Pistoletto, Gilberto Zorio, Alighiero Boetti, Pier Paolo Calzolari, Giovanni Anselmo, Salvo, Giuseppe Penone and Giulio Paolini. From 1975, some of these artists began to use the gallery space as a workshop, creating installations and experimenting with new creative processes. Since then, Persano has dealt with their projects and productions of works, establishing a close collaboration with his artists.
Over the years, he has worked with Michelangelo Pistoletto, Mario Merz, Pier Paolo Calzolari, Jannis Kounellis, Nicola De Maria, Emilio Prini, Gilberto Zorio, Joseph Kosuth, Sol LeWitt, Max Neuhaus, Lawrence Weiner, Franz West, Jan Dibbets, Bernar Venet, Pedro Cabrita Reis, Julião Sarmento, Susana Solano, Costas Varotsos, Avery Preesman, Susan Norrie, Susy Gómez, Lida Abdul, Alfredo Romano, Michele Zaza, Luisa Rabbia, Herbert Brandl, Per Barclay, Marco Bagnoli, Marco Gastini, Alessandro Sciaraffa, Lina Fucà, Michael Biberstein, Zena el Khalil, Paolo Cirio and Nunzio.